Sfoglia Dipartimento di Farmacia e Scienze della Salute e della Nutrizione - Tesi di Dottorato per Titolo
Items 29-48 di 101
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Effetto dell'acido retinoico sulle cellule del leydig: regolazione dell'apoptosi e della steroidogenesi
(2013-06-14)In addition to playing a foundamental role in very diverse processes such as vision and growth and differentiation, vitamin A (retinol) and its main biologically active derivate, retinoic acid (RA), are clearly involved in ... -
Estrogen receptor alpha interferes with LKBl/AMPK/mTOR signaling activation in adiponectin-treated breast cancer cells
(2018-02-27)Breast cancer is the most common type of tumor and the leading cause of cancer-related deaths in women, worldwide. The cause of breast cancer is multifactorial and includes hormonal, genetic and environmental cues. Obesity ... -
Estrogen Receptor beta, through Sp1, recruits a corepressor complex to the Estrogen Receptor alpha gene promoter in breast cancer cells
(2012)Human Estrogen receptors alpha (α) and beta (β) are essential components of a complex signal transduction pathway that regulates mammary growth and development. Several studies have reported that normal breast tissues ... -
FoxO3a reactivation restores the sensitivity to the antiestrogen treatment in tamoxifen resistant breast cancer
(2017-06-12)Resistance to endocrine treatments is a major clinical challenge in the management of estrogen receptor alpha positive (ER+) breast cancers (BC). Although multiple mechanisms leading to endocrine resistance have been ... -
Genomics based discovery and anticancer activity assessment of new thioviridamide-like molecules produced by actinobacteria
(2019-03-21)Fin dalla scoperta della penicillina da parte di Alexander Fleming nel 1928, i prodotti naturali microbici hanno rappresentato una risorsa essenziale per lo sviluppo di nuovi agenti farmacologici. All’interno dell’immenso ... -
GPER mediates the up-regulation of acid synthase (fasn) intuced by 17B-estradiol in cancer cell and in cancer-associated fibroblasts (CAFs)
(2012-11-26)Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of many tumors. Fatty acid synthase (FASN) is a key lipogenic enzyme catalyzing the terminal steps in the de novo biogenesis of ... -
Identification and biochemical-molecular characterization of mitochondrial carrier proteins in human andmodel organisms and associated diseases
(2017-06-12)The mitochondrial carriers (MCs) are transmembrane proteins found in the mitochondrial inner membrane, which catalyze the translocation of solutes through the membrane. These belong to a family of carrier proteins, the ... -
Identificazione del recettore strogenico GPER (G-protein-couple estrogen receptor) nella ghiandola prostatica umana: valutazione del GPER nei tessuti prostateci benigni e neoplastici
(2015-12-18)Gli estrogeni sono coinvolti nella crescita, differenziazione e patogenesi della prostata umana attraverso la mediazione dei classici recettori estrogenici (ER e ER). D'altro canto, il meccanismo non genomico degli ... -
Idrogel funzionali per la veicolazione di principi attivi
(2017-06-12)