Sfoglia Dipartimento di Farmacia e Scienze della Salute e della Nutrizione - Tesi di Dottorato per Titolo
Items 20-39 di 101
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Chenodeoxycholic acid (CDCA) through TGR5-dependent CREB-signaling activation enhances Cyclin D1 expression and promotes human endometrial cancer cell proliferation
(2011)Increasing epidemiologic data in humans as well as many in vitro investigative reports suggest that overweight and obesity are important risk factors for type-I EC which is the most common malignancy in women and accounts ... -
Cratterizzazione degli effetti neuroprotettivi della leptina in un modello sperimentale di ischemia cerebrale focale nel ratto
(2011)La leptina, oltre ad avere effetti sull’ipotalamo per il controllo del peso corporeo, è coinvolta nella regolazione della funzionalità, dello sviluppo e della sopravvivenza neuronale. Studi recenti hanno evidenziato i ... -
Dynamic effects of retinoic acid and its isomers on cancer and physiology
(2010-11-23)In the search for new cancer chemo-preventive compounds, hundreds of naturally occurring molecules have been evaluated. Among these, antioxidants appear to be very promising. In this contest, over the last decade retinoids, ... -
Effects of adiponectin on the progression of breast cancer: role of Estrogen Receptor alpha
(2014-11-28)Adipose tissue is no longer considered an inert tissue for storing energy but is now recognized as an active endocrine organ secreting adipokines, cytokines and a diverse range of inflammatory markers. Adiponectin is ... -
Effects of erythropoietin and stem cell factor on normal and cancer cells: implication for supportive therapy in oncological patients
(2013-10-23)The ability of erythropoietin (Epo) to promote the production of red cells is currently exploited to treat chemotherapy-induced anemia. However, the expression of Epo receptor (EpoR) in a variety of cancer cells suggests ... -
Effetti dell'olio essenziale di Bergamotto (Citrus bergamia Risso et poiteau) su processo autofagico: identificazione dei meccanismi coinvolti e dei componenti responsabili
(2012)Nel presente studio, condotto in vitro, è stato valutato il coinvolgimento del processo autofagico negli effetti biologici dell’olio essenziale di bergamotto, BEO (Citrus Bergamia, Risso et Poiteau), un fitocomplesso ... -
Effetto dell'acido retinoico sulle cellule del leydig: regolazione dell'apoptosi e della steroidogenesi
(2013-06-14)In addition to playing a foundamental role in very diverse processes such as vision and growth and differentiation, vitamin A (retinol) and its main biologically active derivate, retinoic acid (RA), are clearly involved in ... -
Estrogen receptor alpha interferes with LKBl/AMPK/mTOR signaling activation in adiponectin-treated breast cancer cells
(2018-02-27)Breast cancer is the most common type of tumor and the leading cause of cancer-related deaths in women, worldwide. The cause of breast cancer is multifactorial and includes hormonal, genetic and environmental cues. Obesity ... -
Estrogen Receptor beta, through Sp1, recruits a corepressor complex to the Estrogen Receptor alpha gene promoter in breast cancer cells
(2012)Human Estrogen receptors alpha (α) and beta (β) are essential components of a complex signal transduction pathway that regulates mammary growth and development. Several studies have reported that normal breast tissues ...