Tesi di Dottorato: Recent submissions
Items 741-760 di 1621
-
Caratterizzazione del ruolo dell'autofagia in un modello sperimentale di glaucoma acuto
(2011)Il termine glaucoma indica un gruppo eterogeneo di neuropatie ottiche progressive caratterizzate da alterazioni del campo visivo dovute alla morte delle cellule ganglionari retiniche (Retinal Ganglion Cells, RGCs) e alla ... -
Cratterizzazione degli effetti neuroprotettivi della leptina in un modello sperimentale di ischemia cerebrale focale nel ratto
(2011)La leptina, oltre ad avere effetti sull’ipotalamo per il controllo del peso corporeo, è coinvolta nella regolazione della funzionalità, dello sviluppo e della sopravvivenza neuronale. Studi recenti hanno evidenziato i ... -
Chenodeoxycholic acid (CDCA) through TGR5-dependent CREB-signaling activation enhances Cyclin D1 expression and promotes human endometrial cancer cell proliferation
(2011)Increasing epidemiologic data in humans as well as many in vitro investigative reports suggest that overweight and obesity are important risk factors for type-I EC which is the most common malignancy in women and accounts ... -
In vitro mechanism for downregulation of erα expression by epigallocatechim gallate in ER+/PR+ human breast cancer cells
(2013-11-26)La prolungata esposizione agli estrogeni rappresenta un fattore di rischio per lo sviluppo e la progressione del carcinoma mammario, pertanto la terapia antiestrogenica è considerata l’approccio terapeutico di elezione ... -
Modelli sperimentali cellulari e molecolari per la valutazione della tossicità di xenobiotici
(2013-12-02)The aim of my thesis was to find two different experimental models to study cellular and molecular xenobiotics toxicity. In the first part of the present work we studied the interaction between two different plasma ... -
Study of autophagic and epigenetic mechanisms in experimental models of inflammatory and neuropathic pain for the identification of new pharmacological targets
(2013-11-28)Pain is defined by IASP as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage” (IASP, 2011). While physiological pain is like a warning ... -
<<The>> estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness
(2013-12-02)The role of the Forkhead box class O (FoxO)3a transcription factor in breast cancer migration and invasion is controversial. Here we show that FoxO3a overexpression decreases motility, invasiveness, and anchorage-indep ... -
Caratterizzazione pre-clinica di una nuova strategia terapeutica per l'ischemia cerebrale identificata mediante drug repurposing di un antibiotico macrolide
(2013-11-30)Cerebral ischemia is one of the most common causes of disability and mortality worldwide and the only pharmacological treatment currently available is thrombolysis. The understanding of the mechanisms underlying ischemic ... -
A Lévy Walk approach to the propagation of solar energetic particles
(2013-11-26)This thesis is dedicated to the problem of energetic particle propagation in the solar wind, with special emphasis on the propagation of solar energetic particles (SEPs). Those particles are accelerated either in the low ... -
Air quality and pollutant modelling in the mediterranean regionDocumenti elettronici
(2013-11-11)L'inquinamento atmosferico viene de nito come la presenza di sostanze che possono avere e etti dannosi sulla salute umana o sull'intero sistema ambientale (EC, 2008), causando e etti misurabili sugli animali, sulla ... -
Astroparticle physics as a telescope for solar interior, galactic and extragalactic structures
(2013-11-25)Astroparticle physics provide a fundamental tool to investigate the astrophysical structures at different scales. In this thesis the results are presented of three years of research focused on time variations on solar ... -
Novel molecular materials for photo/electro conversion based on Palladium and Iridium organometallic complex
(2013-11-28)Questo lavoro di ricerca è dedicato allo sviluppo di nuovi materiali molecolari basati su complessi ciclometallati di Pd(II) e di Ir(III) per la foto/elettro conversione. Negli ultimi quindici anni, al fine di ottenere ... -
Properties of biomolecules at the interfaces: studies and characterization of chromonic mesogens, from the basis to applications
(2013-11-28)The study of the interaction between molecules, in particular biological molecules and liquid crystals (LC), has experienced a huge growth in the recent years because of the development in devices engineering applied not ...