Sfoglia Tesi di Dottorato per Autore "Andò, Sebastiano"
Items 1-20 di 37
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Action of the E2/ERβ/PTEN signaling in the metabolic reprogramming of TCam 2, human melanoma cell line
De Rose, Daniela; Andò, Sebastiano; Aquila, Saveria (2019-03-21)I tumori maligni più abbondanti nella popolazione maschile di età compresa tra i 17 ed i 45 anni, sono i tumori delle cellule germinali (GCTs). Essi comprendono un gruppo eterogeneo di neoplasie in termini istologici, ... -
Activated FXR inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy
Vircillo, Valentina; Andò, Sebastiano; Catalano, Stefania (2017-06-12)Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, ... -
Advanced mass spectrometric approaches for the determination of food quality and development of new methodologies for enrichment of nutraceuticals in functional foods
Bartella, Lucia; Andò, Sebastiano; Di Donna, Leonardo (2018-02-27)The research works presented in this Ph.D. thesis are based on the nutraceuticals and functional foods research. The first part of the thesis deals with three main topics: 1. Structural characterization of new HMG-flavonoids ... -
Advanced materials for pharmaceutical and biomedical purposes
Mellace, Silvia; Andò, Sebastiano; Cassano, Roberta (2018-02-27)L'innovazione nella chimica dei materiali e nella nanotecnologia hanno sinergicamente contribuito all'avanzamento e allo sviluppo dei Drug Delivery Systems (DDS) creando devices in grado di proteggere farmaci e sostanze ... -
Application of computational methodologies toward the identification of novel therapeutics and photodegradation studies for the design of light-stable formulations
Occhiuzzi, Maria Antonietta; Andò, Sebastiano; Grande, Fedora; Iole, Giuseppina (Università della Calabria, 2021-06-10) -
Benefits of advanced techniques and data processing for the analysis of complex biological and food matrices
Spatari, Claudia; Andò, Sebastiano; Ragno, Gaetano (2019-03-03)Durante i tre anni di dottorato in Medicina Traslazionale, il mio lavoro di ricerca si è concentrato sull'applicazione di tecniche analitiche avanzate e sull'elaborazione dei dati per lo studio di matrici complesse biologiche ... -
Charatterization of store-operated calcium entry in the neuroimmune response evoked by ischemic preconditioning in mice subjected to middle cerebral artery occlusion
Frisina, Marialaura; Andò, Sebastiano; Amantea, Diana (Università della Calabria, 2021-06-10)Cerebral ischemia is one of the leading causes of death and long-term disability worldwide. Currently approved therapies for ischemic stroke are limited to reperfusion through mechanical recanalization and/or pharmacological ... -
A computational mechanistic study of potentially evolving platinum based anticancer drugs
Dabbish, Eslam; Andò, Sebastiano; Sicilia, Emilia (Università della Calabria, 2021)Metals are known to play a fundamental physiological role inside human body affecting many of the biological functions. Analogously, metal based drugs can also have a similar impact. Cisplatin, a simple platinum complex, is ... -
Computational study of new drugs for photodynamic therapy
Pirillo, Jenny; Andò, Sebastiano; Russo, Nino; Mazzone, Gloria (2017-05-05)Photodynamic'therapy'(PDT)'is'a'non:invasive'therapeutic'technique' for' the' treatment' of' different' kind' of' tumours' through' the' production' of' reactive'oxygen'species'(ROS)'that'act'as'cytotoxic'agents.'''' PDT'works' ... -
Design, synthesis and characterization of biologically active heterocyclic organic compounds
Algieri, Vincenzo; Andò, Sebastiano; De Nino, Antonio (2018-04-13) -
Development and optimization of analytical protocols based on microextraction techniques for clinical screening and environmental control
Elliani, Rosangela; Andò, Sebastiano; Tagarelli, Antonio (2019-03-21)The development of analytical protocols for the determination of analytes at trace levels in complex matrices (e.g. biological fluids or contaminated water) is a crucial point for the environmental assessment and monitoring ... -
Eco-friendly extraction of bioactive compounds from olive (drupes and leaves), Stevia and Schizochytrium sp.
Santoro, Ilaria; Andò, Sebastiano; Sindona, Giovanni; Nardi, Monica (2017-04-13)The use of nutraceutical compounds, as well as their extraction from natural sources, is now the subject of studies in various sectors. The research groups working in this field focus their attention on the optimization ... -
Estratti naturali ad azione polivalente sui pathway di alterazioni metaboliche
Casacchia, Teresa; Andò, Sebastiano; Statti, Giancarlo (2018-02-27) -
Estrogen receptor alpha interferes with LKBl/AMPK/mTOR signaling activation in adiponectin-treated breast cancer cells
Naimo, Giuseppina Daniela; Andò, Sebastiano; Panno, Maria Luisa; Mauro, Loredana (2018-02-27)Breast cancer is the most common type of tumor and the leading cause of cancer-related deaths in women, worldwide. The cause of breast cancer is multifactorial and includes hormonal, genetic and environmental cues. Obesity ... -
Estrogen Receptor beta, through Sp1, recruits a corepressor complex to the Estrogen Receptor alpha gene promoter in breast cancer cells
Zito, Domenico; Sisci, Diego; Andò, Sebastiano (2012)Human Estrogen receptors alpha (α) and beta (β) are essential components of a complex signal transduction pathway that regulates mammary growth and development. Several studies have reported that normal breast tissues ... -
FoxO3a reactivation restores the sensitivity to the antiestrogen treatment in tamoxifen resistant breast cancer
Donà, Ada Alice; Andò, Sebastiano; Sisci, Diego (2017-06-12)Resistance to endocrine treatments is a major clinical challenge in the management of estrogen receptor alpha positive (ER+) breast cancers (BC). Although multiple mechanisms leading to endocrine resistance have been ... -
Genomics based discovery and anticancer activity assessment of new thioviridamide-like molecules produced by actinobacteria
Frattaruolo, Luca; Andò, Sebastiano; Cappello, Anna Rita (2019-03-21)Fin dalla scoperta della penicillina da parte di Alexander Fleming nel 1928, i prodotti naturali microbici hanno rappresentato una risorsa essenziale per lo sviluppo di nuovi agenti farmacologici. All’interno dell’immenso ... -
Identification and biochemical-molecular characterization of mitochondrial carrier proteins in human andmodel organisms and associated diseases
Muto, Luigina; Andò, Sebastiano; Dolce, Vincenza (2017-06-12)The mitochondrial carriers (MCs) are transmembrane proteins found in the mitochondrial inner membrane, which catalyze the translocation of solutes through the membrane. These belong to a family of carrier proteins, the ... -
Idrogel funzionali per la veicolazione di principi attivi
Spataro, Tania; Andò, Sebastiano; Picci, Nevio (2017-06-12) -
Inhibition of estrogen-dependent cyclin D1 expression by androgen receptor in MCF-7 breast cancer cell
Casaburi, Ivan; Andò, Sebastiano (2007-11-30)